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Well, you can scan the repack before installing. Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells.

The precursor for synthesis of spermine is the amino acid ornithine. It is an essential growth factor in some bacteria as well. It is found as a polycation at physiological pH.

Spermine is associated with nucleic acids and is thought to stabilize helical structure, particularly in viruses.

Crystals of spermine phosphate were first described in , in human semen , by Antonie van Leeuwenhoek. Spermine biosynthesis in animals starts with decarboxylation of ornithine by the enzyme Ornithine decarboxylase in the presence of PLP.

This decarboxylation gives putrescine. Thereafter the enzyme spermidine synthase effects two N-alkylation by decarboxy- S-Adenosyl methionine.

The intermediate is spermidine. Plants employ additional routes to spermine. In one pathway L-glutamine is the precursor to L-ornithine, after which the synthesis of spermine from L-ornithine follows the same pathway as in animals.

Another pathway in plants starts with decarboxylation of L-arginine to produce agmatine. The imine functional group in agmatine then is hydrolysed by agmatine deiminase , releasing ammonia , converting the guanidine group into a urea.

The resulting N-carbamoylputrescine is acted on by a hydrolase to split off urea group, leaving putrescine. After that the putrescine follows the same pathway to completing the synthesis of spermine.

From Wikipedia, the free encyclopedia. Polyamine involved in cellular metabolism. For other uses, see BESM disambiguation.

Genetic and Rare Diseases Information Center Congenital insensitivity to pain with anhidrosis. Patient Support and Advocacy Resources Disease InfoSearch National Organization for Rare Disorders NORD.

Research Studies from ClinicalTrials. Scientific Articles on PubMed PubMed. References Indo Y, Tsuruta M, Hayashida Y, Karim MA, Ohta K, Kawano T, Mitsubuchi H, Tonoki H, Awaya Y, Matsuda I.

Nat Genet. Citation on PubMed Indo Y. Molecular basis of congenital insensitivity to pain with anhidrosis CIPA : mutations and polymorphisms in TRKA NTRK1 gene encoding the receptor tyrosine kinase for nerve growth factor.

Hum Mutat. Citation on PubMed Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol.

Citation on PubMed Miranda C, Di Virgilio M, Selleri S, Zanotti G, Pagliardini S, Pierotti MA, Greco A. J Biol Chem.

Epub Nov Citation on PubMed Verhoeven K, Timmerman V, Mauko B, Pieber TR, De Jonghe P, Auer-Grumbach M. Recent advances in hereditary sensory and autonomic neuropathies.

Curr Opin Neurol. Citation on PubMed Verpoorten N, De Jonghe P, Timmerman V.

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